INTRODUCTION

Phosphoinositide dependent protein kinase-1 (PDK1) is a "master" protein kinase in insulin and growth factor signalling. Stimulation of cells with insulin and growth factors leads to the generation of
the phospholipid second messengers phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) and PtdIns(3,4)P2 through activation of PI3 kinase. These second messengers trigger the activation of a complex protein kinase network, which is responsible for basic cellular processes such as cell growth and cell division. The Ser/Thr protein kinase 3-phosphoinositide dependent protein kinase 1 (PDK1)
is responsible for the activation of at least 24 different protein kinases in this network, such as protein kinase B (PKB), p70 S6 kinase (S6K), and serum and glucocorticoid responsive kinase (SGK). PDK1 phosphorylates its substrate kinases in their T-loop (also called activation segment), which leads to the activation of the respective kinase. Because of it's early and central role in this signalling network, PDK1 has been termed a "master kinase". Sequence analysis predicted that the 556-amino acid PDPK1 protein contains a catalytic domain with 11 classic kinase subdomains and a C-terminal pleckstrin homology (PH) domain. (Reference : David Kommander and OMIM)

FEATURES

					SOURCE/COURTESY
1	Aliases	MGC20087 (LL) MGC35290 (LL) PDK1 (LL) PRO0461 (LL) 3-phosphoinositide dependent protein kinase-1 (GDB, LL, HUGO) PkB kinase (LL) 3-phosphoinositide dependent protein kinase-1 (EC 2.7.1.37) (hPDK1). (SP)			Gene Card
2	Sequence Information	Length: 556 AA Molecular weight: 63151 Da Secondy Structure By Joy			Swiss Prot
3	Location	Alessi et al. (1997) and Stephens et al. (1998) mapped the PDPK1 gene to 16p13.3 based on its identity to a sequence located in the same region as the PKD1 (601313) and TSC2 (191092) loci (Burn et al., 1996).			Gene Card , Locus Link Gene map locus 16p13.3
4	Homologs for the protein	1: HomoloGene:1961. Gene conserved in Mammalia 2: HomoloGene:36580. Gene conserved in Eukaryota 3: HomoloGene:1963. Gene conserved in Fungi/Metazoa group      4: HomoloGene:20962. Gene conserved in Fungi/Metazoa group 5: HomoloGene:2058. Gene conserved in Mammalia			NCBI homologene
5	Structure	Assumed Biological Molecule	Assymetric Unit	C Alpha Cartoon	PDB PDB Summary Information DeepView for Calpha Cartoon
6	Domain Information	IPR000719 Protein kinase IPR001245 Tyrosine protein kinase IPR002290 Serine/threonine protein kinase IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like IPR011036 Pleckstrin-homology-related   PDB			InterPro
7	Evolution of PDK1	Reference Key First accession number is the SwissProt ID: (www.expasy.ch/sprot)   Second accession number is the LocusLink ID: (www.ncbi.nlm.nih.gov/LocusLink)			www.cellsignal.com
8	Research Articles on PDK1	PubMed on PDK1			NCBI/PubMed